Contract · Federal · No Set aside used

Assay Service for assessing ADME properties and in vivo PK properties with the selected vendor. ENAMINE US INC

Agency: HEALTH AND HUMAN SERVICES, DEPARTMENT OF / NATIONAL INSTITUTES OF HEALTH
Location: Bethesda, MD
Amount: Amount not listed
Posted: Sep 10, 2026
Set-aside: No Set aside used
NAICS code: 424690 look up NAICS codes
PSC code: 6505

Timeline

Posted

Sep 10, 2026
Status

Closing soon

What contracts like this typically pay

No award history yet for this category (NAICS 424690).

What this contract is for

Agency: HEALTH AND HUMAN SERVICES, DEPARTMENT OF / NATIONAL INSTITUTES OF HEALTH
Location: Bethesda, MD
Set-aside: No Set aside used
NAICS: 424690
Scope: Federal

The Section on Medicinal Chemistry (SMC) develops new molecular entities with implications in improving health and treatment for various metabolic and alcohol associated diseases.

To assess the translational potential of novel molecular entities, which would allow us to make decisions to proceed the compounds for further development we utilize multiple derisking assays.

These assays comprise of both cell-based (in vitro) testing and then eventually in mice to assess pharmacokinetic parameters to see if the drug is orally available.

Request to procure Chemical Reagent (Assay) Development & Laboratory Testing Service SMC to produce grouped ADME assays and perform a Pharmacokinetic study in C57BL6 mice.

By including the Caco-2 Permeability Assay in our ADME evaluation it'll accurately predict the oral absorption potential of our compounds.

This well-established in vitro model closely mimics the human intestinal epithelium, providing critical insights into a compound’s passive diffusion, active transport, and efflux processes, such as those mediated by P-glycoprotein (P-gp).

The data generated from this assay are vital for informing structure-activity relationship (SAR) optimization, improving compound permeability, and reducing transporter-related liabilities that could hinder bioavailability

Official solicitation and documents

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View the official listing on SAM.gov

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