Contract · Federal · No Set aside used

TECHNOLOGY LICENSING OPPORTUNITY: Bacterial Lipid Nanodiscs Platform

Agency: ENERGY, DEPARTMENT OF / ENERGY, DEPARTMENT OF
Location: Los Alamos, NM
Amount: Amount not listed
Posted: Jun 15, 2026
Set-aside: No Set aside used
NAICS code: 541715 - Scientific Research and Development Services (general category) look up NAICS codes
PSC code: AJ11

Timeline

Posted

Jun 15, 2026
Status

Open now

What contracts like this typically pay

No award history yet for this category (NAICS 541715).

What this contract is for

Agency: ENERGY, DEPARTMENT OF / ENERGY, DEPARTMENT OF
Location: Los Alamos, NM
Set-aside: No Set aside used
NAICS: 541715 - Scientific Research and Development Services (general category)
Scope: Federal

The Bacterial Lipid Nanodiscs Platform developed by Los Alamos National Laboratory provides a new way to study entire bacterial membranes in a controlled, nanoscale format derived directly from native lipid extracts.

Researchers gain access to membrane components that typically remain difficult to isolate, stabilize or analyze, enabling more accurate evaluation of immunogenic lipids and membrane?associated targets.

The platform offers a safer alternative to handling live high?risk pathogens while preserving the biological context that drives meaningful insights for vaccine design and antimicrobial discovery such as therapeutic antibodies to conserved lipids on bacterial membranes.

How it Works The Bacterial Lipid Nanodiscs Platform creates uniform nanoscale discs from total lipid extracts harvested from bacterial membranes.

Membrane scaffold protein MSP1D1 encases the lipid mixture and forms a stable disc roughly 10 nanometers wide.

The resulting particles retain the full complement of native bacterial lipids, arranged in a membrane?like environment that supports realistic biological interactions without requiring synthetic lipids or live cells.

Technical Description The method adapts established nanodisc assembly techniques to incorporate entire bacterial lipid extracts rather than defined synthetic lipid mixtures.

Total lipids from a pathogen are solubilized, combined with MSP1D1 and dialyzed under controlled conditions to allow the scaffold protein to form a discoidal structure around the heterogeneous lipid population.

The process yields nanoparticles that represent the membrane environment of the source organism, including amphiphilic molecules that typically resist purification or structural study when isolated from their native context.

The approach was demonstrated using...

Official solicitation and documents

The full solicitation, any attachments, and the actual submission instructions live on the official listing, not on this page. Oppward summarizes public record data; it does not host or mirror the source documents.

View the official listing on SAM.gov

Oppward is an independent service and is not affiliated with, endorsed by, or sponsored by SAM.gov or any government agency. This page is a plain-English summary of public record data; the linked source above is the authoritative listing.

How to bid on this

This is a contract solicitation, not a grant. To bid, you submit a proposal (usually a price and a description of how you would do the work) directly to the government, through the channel the official listing specifies, not through Oppward.

Make sure your business has an active SAM.gov registration. You cannot be paid on a federal contract without one.
Read the full solicitation on the official listing above, especially the scope of work, not just this summary. Our guide to reading a solicitation walks through what to look for.
Check the set-aside listed above and confirm your business actually qualifies for it before you spend time on a proposal. See our guide to set-asides if the category is unfamiliar.
Submit your proposal by the deadline, using the exact submission method the official listing states. A technically on-time bid sent the wrong way is often treated as late.