Contract · Federal

Protein ENGineering (PENG)

Agency: DEPT OF DEFENSE / DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA)
Location: ARLINGTON, VA
Amount: Amount not listed
Posted: Aug 7, 2026
Set-aside: None (open competition)
NAICS code: 541714 - Scientific Research and Development Services (general category) look up NAICS codes
PSC code: AC12

Timeline

Posted

Aug 7, 2026
Status

Open now

What contracts like this typically pay

No award history yet for this category (NAICS 541714).

What this contract is for

Agency: DEPT OF DEFENSE / DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA)
Location: ARLINGTON, VA
NAICS: 541714 - Scientific Research and Development Services (general category)
Scope: Federal

The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals for the development of a multifunctional, target-agnostic platform for precise, programmable editing of endogenous proteins.

The goal of the Protein ENGineering (PENG) program is to transition proteome engineering from a collection of isolated, bespoke tools into a universal, software-defined discipline.

The PENG program will establish a comprehensive, integrated platform composed of modular targeting, generalizable effector chemistries, and multiplexed control systems.

Rather than developing isolated, target-specific tools, performers will integrate novel splicing, ligation, and co-translational techniques to directly recognize, modify, and rewrite endogenous proteins within complex biological architectures.

Performers may explore multiple technical paths, progressively advancing their approaches from foundational validation to robust demonstrations of efficacy.

Ultimately, this integrated platform will be validated in high-fidelity cellular models (e.g., organoids), to provide an integrated proof-of-concept at the tissue level.

Official solicitation and documents

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